DPY19L2P4

Across TCGA pan-cancer cohorts, DPY19L2P4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DPY19L2P4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where DPY19L2P4 RNA is repressed in tumor relative to normal tissue. In most cancer types DPY19L2P4 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where DPY19L2P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPY19L2P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.390	<.001	11	view →
THCA	Male	III,IV	−1.277	<.001	10	view →
KIRC	Male	All	−0.771	<.001	8	view →
KIRP	All	All	−0.479	<.001	5	view →
UCEC	All	II,III,IV	−0.631	.018	4	view →
LUAD	Female	II,III,IV	−0.249	.015	3	view →
LUSC	All	III,IV	−0.236	.002	3	view →
HNSC	Female	IV	−0.058	.014	3	view →
PRAD	All	All	+0.371	.003	2	view →
STAD	All	All	−0.087	.030	2	view →
BRCA	Female	All	−0.271	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DPY19L2P4–KICH

Open the KICH breakdown →