DPY19L2

Across TCGA patient cohorts, DPY19L2 mutation is significantly associated with the RNA expression of many other genes, with 5,070 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPY19L2-associated genes across cancer lineages are DYNC2I2, PKN3, and RNU6-528P. Each is linked with DPY19L2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DPY19L2-to-partner and partner-to-DPY19L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYNC2I2 grouped by DPY19L2-low versus DPY19L2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPY19L2→partner) and Y-score (partner→DPY19L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DYNC2I2 →	+0.636	+3.616	.005	.001	3	4
UCEC	PKN3 →	+0.623	+2.126	<.001	<.001	3	4
LUSC	RNU6-528P →	+0.130	+3.008	.002	.008	3	4
CESC	LINC01072 →	+0.315	+5.345	<.001	.001	3	3
UCEC	TAF9 →	+0.684	+2.807	<.001	<.001	3	3
UCEC	C4orf3 →	+0.576	+1.868	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,070 associations by consensus.

DYNC2I2 by DPY19L2 expression — SKCM

Explore this box plot interactively →