DPY19L2

Across TCGA patient cohorts, DPY19L2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPY19L2-associated genes across cancer lineages are Cyclin-E2, FASN, and 14-3-3_beta. Each is linked with DPY19L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPY19L2-to-partner and partner-to-DPY19L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by DPY19L2-low versus DPY19L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPY19L2→partner) and Y-score (partner→DPY19L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.128	+1.884	.028	.030	3	3
LUAD	FASN →	+0.414	+2.459	.044	.020	3	2
UCEC	14-3-3_beta →	-0.075	-1.973	.032	.029	3	2
UCEC	Gab2 →	+0.371	+2.115	.002	.017	3	2
UCEC	Mre11 →	-0.070	-1.847	.019	.049	3	2
UCEC	Shc_pY317 →	-0.147	-3.169	.005	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Cyclin-E2 by DPY19L2 expression — UCEC

Explore this box plot interactively →