DPY19L1

Across TCGA patient cohorts, DPY19L1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPY19L1-associated genes across cancer lineages are p62 Lck ligand, 14-3-3_beta, and EGFR_pY1068. Each is linked with DPY19L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPY19L1-to-partner and partner-to-DPY19L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by DPY19L1-low versus DPY19L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPY19L1→partner) and Y-score (partner→DPY19L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.300	+2.469	.021	.010	3	2
LUSC	14-3-3_beta →	-0.133	-2.990	.028	.036	3	1
UCEC	EGFR_pY1068 →	-0.252	-2.584	.012	.010	3	1
UCEC	eIF4E →	+0.185	+1.906	.029	.016	3	1
UCEC	MEK1 →	+0.373	+2.584	.011	.010	3	1
UCEC	MSH2 →	-0.319	-3.433	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

p62 Lck ligand by DPY19L1 expression — UCEC

Explore this box plot interactively →