DPY19L1

Across TCGA cell cohorts, DPY19L1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DPY19L1-associated genes across cancer lineages are SOX3, PYHIN1, and VPREB1. Each is linked with DPY19L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPY19L1-to-partner and partner-to-DPY19L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX3 grouped by DPY19L1-low versus DPY19L1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPY19L1→partner) and Y-score (partner→DPY19L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SOX3 →	+0.038	+3.115	.001	.004	3	2
LUNG_SCLC	PYHIN1 →	+0.078	+3.624	<.001	.005	3	1
LUNG_SCLC	VPREB1 →	+0.089	+3.256	.003	.005	3	1
LUNG_SCLC	TEX37 →	+0.091	+3.624	<.001	.005	3	1
LUNG_SCLC	SFT2D3 →	+1.133	+3.791	<.001	.003	3	1
LUNG_SCLC	AWAT1 →	+0.331	+3.491	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SOX3 by DPY19L1 expression — LARGE_INTESTINE

Explore this box plot interactively →