DPT

Across TCGA patient cohorts, DPT mutation is significantly associated with the RNA expression of many other genes, with 790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPT-associated genes across cancer lineages are ZFYVE19, DOLPP1, and LMNB2. Each is linked with DPT in more than 1 cancer types. Because this analysis shows association rather than direction, both DPT-to-partner and partner-to-DPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFYVE19 grouped by DPT-low versus DPT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPT→partner) and Y-score (partner→DPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZFYVE19 →	+0.484	+3.609	<.001	.001	3	2
UCEC	DOLPP1 →	+0.557	+3.010	.001	<.001	3	2
UCEC	LMNB2 →	+0.609	+3.708	.005	<.001	3	2
UCEC	WDR76 →	+0.813	+3.021	<.001	<.001	3	2
SKCM	LINC02814 →	+0.211	+2.703	.002	.006	3	2
UCEC	JOSD1 →	+0.499	+3.584	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 790 associations by consensus.

ZFYVE19 by DPT expression — UCEC

Explore this box plot interactively →