DPT

Across TCGA patient cohorts, DPT mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPT-associated genes across cancer lineages are FASN, FoxM1, and Rad50. Each is linked with DPT in more than 1 cancer types. Because this analysis shows association rather than direction, both DPT-to-partner and partner-to-DPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by DPT-low versus DPT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPT→partner) and Y-score (partner→DPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.497	+3.169	.005	.019	3	1
UCEC	FoxM1 →	+0.280	+2.000	.016	.032	3	1
UCEC	Rad50 →	-0.285	-3.807	.009	<.001	3	1
UCEC	VHL →	-0.707	-2.000	.021	.032	3	1
UCEC	Cyclin-B1 →	+0.566	+3.000	.025	.036	3	1
UCEC	Di-Ras3 →	-0.136	-2.000	.041	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FASN by DPT expression — UCEC

Explore this box plot interactively →