DPT

Across TCGA cell cohorts, DPT mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPT-associated genes across cancer lineages are DEFA4, ETDC, and MAGEB4. Each is linked with DPT in more than 1 cancer types. Because this analysis shows association rather than direction, both DPT-to-partner and partner-to-DPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by DPT-low versus DPT-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPT→partner) and Y-score (partner→DPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFA4 →	+0.042	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	ETDC →	+0.523	+5.228	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ZNF804B →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.336	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

DEFA4 by DPT expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →