Across TCGA patient cohorts, DPRX mutation is significantly associated with the RNA expression of many other genes, with 1,061 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPRX-associated genes across cancer lineages are INCENP, NCAPD3, and CCNB2. Each is linked with DPRX in more than 1 cancer types. Because this analysis shows association rather than direction, both DPRX-to-partner and partner-to-DPRX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPRX→partner) and Y-score (partner→DPRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INCENP →	+0.639	+2.593	.003	.006	3	2
UCEC	NCAPD3 →	+0.641	+2.098	<.001	.003	3	2
UCEC	CCNB2 →	+0.610	+2.584	.008	.001	3	2
UCEC	MON1A →	+0.492	+3.818	<.001	<.001	3	2
SKCM	POC1A →	+0.651	+3.751	<.001	<.001	3	2
UCEC	PLK1 →	+0.658	+2.087	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,061 associations by consensus.

Exploration

DPRX survival (RNA) · tumor vs normal (RNA) · all DPRX data types