Across TCGA patient cohorts, DPRX mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPRX-associated genes across cancer lineages are PCNA, EGFR_pY1068, and EGFR. Each is linked with DPRX in more than 1 cancer types. Because this analysis shows association rather than direction, both DPRX-to-partner and partner-to-DPRX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPRX→partner) and Y-score (partner→DPRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.234	+2.415	.007	.003	3	2
UCEC	EGFR_pY1068 →	-0.277	-3.584	.005	.002	3	1
UCEC	EGFR →	-0.172	-3.143	.007	.018	3	1
UCEC	A-Raf_pS299 →	-0.129	-3.584	.007	.002	3	1
UCEC	ERK2 →	+0.208	+2.459	.007	.018	3	1
UCEC	ACVRL1 →	-0.135	-1.980	.014	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

DPRX survival (RNA) · tumor vs normal (RNA) · all DPRX data types