DPPA4

Across TCGA pan-cancer cohorts, DPPA4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DPPA4 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher DPPA4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DPPA4 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

SARC, UCEC, and SKCM are the cancer types where DPPA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →
LUSC	OS	Median	II,III,IV	0.868	0.392	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DPPA4–SARC (DFS)

Open the SARC breakdown →