DPP8

Across TCGA patient cohorts, DPP8 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPP8-associated genes across cancer lineages are ATM, 4E-BP1, and ACC1. Each is linked with DPP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPP8-to-partner and partner-to-DPP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DPP8-low versus DPP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPP8→partner) and Y-score (partner→DPP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.357	-1.807	.020	.025	3	3
COAD	4E-BP1 →	+0.317	+2.815	.008	.036	2	3
UCEC	ACC1 →	+0.279	+3.472	.024	.002	3	2
UCEC	Akt_pS473 →	+0.588	+1.700	.015	.040	3	2
UCEC	Akt_pT308 →	+0.574	+2.807	.007	.002	3	2
UCEC	STAT3_pY705 →	-0.223	-1.405	.012	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by DPP8 expression — UCEC

Explore this box plot interactively →