DPP8

Across TCGA cell cohorts, DPP8 mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPP8-associated genes across cancer lineages are SHCBP1L, FCRL4, and CLEC6A. Each is linked with DPP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPP8-to-partner and partner-to-DPP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1L grouped by DPP8-low versus DPP8-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPP8→partner) and Y-score (partner→DPP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SHCBP1L →	+0.027	+3.843	.001	.007	3	2
LUNG_SCLC	FCRL4 →	+0.016	+5.643	<.001	.002	3	1
LUNG_SCLC	CLEC6A →	+0.126	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	OXT →	+0.033	+3.523	.002	.009	3	1
BLOOD_Lymphoma	CEACAM3 →	+0.121	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	ADGRD2 →	+0.052	+4.321	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

SHCBP1L by DPP8 expression — BLOOD_Lymphoma

Explore this box plot interactively →