DPP6

Across TCGA patient cohorts, DPP6 mutation is significantly associated with the RNA expression of many other genes, with 6,728 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPP6-associated genes across cancer lineages are CENPU, MAMDC2, and RACGAP1. Each is linked with DPP6 in more than 4 cancer types. Because this analysis shows association rather than direction, both DPP6-to-partner and partner-to-DPP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by DPP6-low versus DPP6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPP6→partner) and Y-score (partner→DPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CENPU →	+0.589	+2.450	.004	.001	3	5
LUAD	MAMDC2 →	-0.880	-2.321	.001	.006	3	5
SCLC	RACGAP1 →	+3.801	+3.661	.002	.002	3	4
HNSC	ACTR3B →	+0.496	+3.853	.001	<.001	3	4
UCEC	BRI3BP →	+0.670	+2.332	<.001	<.001	3	4
LUAD	MAD2L1 →	+0.768	+2.723	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,728 associations by consensus.

CENPU by DPP6 expression — LUAD

Explore this box plot interactively →