DPP6

Across TCGA patient cohorts, DPP6 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPP6-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and eIF4E. Each is linked with DPP6 in more than 5 cancer types. Because this analysis shows association rather than direction, both DPP6-to-partner and partner-to-DPP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DPP6-low versus DPP6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPP6→partner) and Y-score (partner→DPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.003	+1.815	<.001	.016	3	6
UCEC	ASNS →	+0.465	+1.509	<.001	<.001	3	5
UCEC	eIF4E →	+0.192	+1.509	<.001	<.001	3	4
LUAD	FoxM1 →	+0.314	+3.033	.002	.017	3	3
COAD	INPP4B →	-0.569	-3.700	<.001	.001	2	4
UCEC	GAPDH →	+0.285	+1.222	.039	.029	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Caspase-7-cleavedD198 by DPP6 expression — COAD

Explore this box plot interactively →