Across TCGA patient cohorts, DPP4 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPP4-associated genes across cancer lineages are TIGAR, ATM, and 4E-BP1. Each is linked with DPP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPP4-to-partner and partner-to-DPP4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPP4→partner) and Y-score (partner→DPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.139	+1.557	.002	.002	3	2
UCEC	ATM →	-0.370	-1.321	.006	.012	3	2
UCEC	4E-BP1 →	+0.239	+2.906	.003	.001	3	2
UCEC	EGFR_pY1068 →	-0.251	-1.925	<.001	.004	3	1
UCEC	eIF4E →	+0.125	+1.847	.049	.007	3	1
UCEC	A-Raf_pS299 →	-0.124	-2.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

DPP4 survival (RNA) · tumor vs normal (RNA) · all DPP4 data types