DPP3

Across TCGA cell cohorts, DPP3 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPP3-associated genes across cancer lineages are DNAI2, SH3GL2, and MSGN1. Each is linked with DPP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPP3-to-partner and partner-to-DPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAI2 grouped by DPP3-low versus DPP3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPP3→partner) and Y-score (partner→DPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DNAI2 →	+0.126	+3.523	<.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.444	+3.474	<.001	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.061	+3.023	<.001	.002	3	1
LARGE_INTESTINE	ATP5F1A →	+0.889	+3.082	.002	.007	3	1
LARGE_INTESTINE	RSPH10B2 →	+0.139	+3.292	.004	.004	3	1
LARGE_INTESTINE	TNK1 →	+0.758	+3.064	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

DNAI2 by DPP3 expression — URINARY_TRACT

Explore this box plot interactively →