DPM2

Across TCGA patient cohorts, DPM2 mutation is significantly associated with the RNA expression of many other genes, with 337 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DPM2-associated genes across cancer lineages are SLC38A8, COX5A, and MIR3927. Each is linked with DPM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPM2-to-partner and partner-to-DPM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC38A8 grouped by DPM2-low versus DPM2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPM2→partner) and Y-score (partner→DPM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SLC38A8 →	+2.551	+3.667	<.001	.001	3	2
SKCM	COX5A →	+0.606	+3.484	<.001	.002	3	2
UCEC	MIR3927 →	+0.219	+4.885	<.001	.002	3	2
SKCM	RNU6-781P →	+0.226	+2.575	<.001	.004	3	2
SKCM	E2F1 →	+0.626	+3.591	.009	.001	3	2
SKCM	GOT1 →	+0.675	+3.217	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 337 associations by consensus.

SLC38A8 by DPM2 expression — SKCM

Explore this box plot interactively →