DPM2

Across TCGA patient cohorts, DPM2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DPM2-associated genes across cancer lineages are Smac, TIGAR, and CD49b. Each is linked with DPM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPM2-to-partner and partner-to-DPM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smac grouped by DPM2-low versus DPM2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPM2→partner) and Y-score (partner→DPM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smac →	+0.376	+2.820	.007	.035	3	1
SKCM	TIGAR →	+0.140	+2.820	.036	.035	3	1
SKCM	CD49b →	-0.315	-3.304	.009	.010	3	1
SKCM	4E-BP1_pT70 →	+0.222	+2.186	.018	.034	3	1
SKCM	DJ-1 →	+0.295	+3.339	.001	.005	3	1
SKCM	EGFR_pY1068 →	-0.216	-3.304	.010	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Smac by DPM2 expression — SKCM

Explore this box plot interactively →