DPM1

Across TCGA patient cohorts, DPM1 mutation is significantly associated with the RNA expression of many other genes, with 521 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPM1-associated genes across cancer lineages are RNU6-73P, RNA5SP176, and RNU6-468P. Each is linked with DPM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPM1-to-partner and partner-to-DPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-73P grouped by DPM1-low versus DPM1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPM1→partner) and Y-score (partner→DPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-73P →	+0.369	+5.410	<.001	.005	3	3
LUSC	RNA5SP176 →	+0.351	+7.924	<.001	.008	3	2
LUAD	RNU6-468P →	+0.361	+5.279	<.001	.006	3	2
LUAD	MIR3194 →	+0.504	+5.410	<.001	.005	3	2
BRCA	RNU6-938P →	+0.559	+4.646	<.001	.008	3	2
BLCA	CYP2A7P1 →	+0.150	+5.588	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 521 associations by consensus.

RNU6-73P by DPM1 expression — LUAD

Explore this box plot interactively →