DPM1

Across TCGA patient cohorts, DPM1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPM1-associated genes across cancer lineages are 14-3-3_beta, Tuberin, and C-Raf. Each is linked with DPM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPM1-to-partner and partner-to-DPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by DPM1-low versus DPM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPM1→partner) and Y-score (partner→DPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.151	-2.973	.009	.035	3	1
UCEC	Tuberin →	+0.420	+2.817	.006	.036	2	1
UCEC	C-Raf →	+0.174	+3.000	.035	.037	2	1
UCEC	p62 Lck ligand →	+0.579	+3.000	.002	.037	1	1
UCEC	VHL →	-1.006	-3.000	.010	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

14-3-3_beta by DPM1 expression — UCEC

Explore this box plot interactively →