DPM1

Across TCGA cell cohorts, DPM1 mutation is significantly associated with the mutation status of many other genes, with 1,981 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPM1-associated genes across cancer lineages are VAC14, CPPED1, and PMFBP1. Each is linked with DPM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPM1-to-partner and partner-to-DPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VAC14 grouped by DPM1-low versus DPM1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPM1→partner) and Y-score (partner→DPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VAC14 →	+4.857	+4.297	.009	.009	1	2
BREAST	CPPED1 →	+4.857	+4.297	.009	.009	1	2
BREAST	PMFBP1 →	+4.857	+4.297	.009	.009	1	2
BREAST	STK35 →	+4.857	+4.297	.009	.009	1	2
BREAST	CCDC33 →	+4.857	+4.297	.009	.009	1	2
BREAST	KCNMA1 →	+3.857	+4.807	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,981 associations by consensus.

VAC14 by DPM1 expression — BREAST

Explore this box plot interactively →