DPH7

Across TCGA patient cohorts, DPH7 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPH7-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and PDCD4. Each is linked with DPH7 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPH7-to-partner and partner-to-DPH7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by DPH7-low versus DPH7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPH7→partner) and Y-score (partner→DPH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.203	+2.584	.023	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.171	-2.321	.029	.034	3	1
UCEC	PDCD4 →	-0.462	-2.312	.035	.034	3	1
UCEC	Shc_pY317 →	-0.181	-2.321	.010	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+0.595	+2.341	.031	.019	3	1
UCEC	c-Kit →	-0.226	-2.584	.038	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ERK2 by DPH7 expression — UCEC

Explore this box plot interactively →