DPH6

Across TCGA pan-cancer cohorts, DPH6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DPH6 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DPH6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DPH6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where DPH6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.409	0.941	.010	7	view →
UCEC	DFS	Median	All	0.961	0.846	.004	4	view →
LSCC	DFS	Quartile	All	0.811	0.510	.033	3	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
CCRCC	DFS	Quartile	III,IV	0.939	0.646	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DPH6–LUAD (DFS)

Open the LUAD breakdown →