DPH6

Across TCGA patient cohorts, DPH6 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPH6-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and p21. Each is linked with DPH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPH6-to-partner and partner-to-DPH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DPH6-low versus DPH6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPH6→partner) and Y-score (partner→DPH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.255	-2.321	.024	.034	3	1
UCEC	mTOR_pS2448 →	-0.157	-2.000	.019	.032	3	1
UCEC	p21 →	+0.258	+3.472	.002	.002	3	1
UCEC	PDCD4 →	-0.669	-2.000	.001	.032	3	1
UCEC	Annexin-1 →	+0.548	+3.019	.020	.019	3	1
UCEC	SF2 →	-0.133	-2.687	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by DPH6 expression — UCEC

Explore this box plot interactively →