DPH5

Across TCGA pan-cancer cohorts, DPH5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DPH5 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DPH5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DPH5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

CCRCC, LSCC, and COAD are the cancer types where DPH5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	IV	0.137	0.861	.024	14	view →
LSCC	OS	Median	II,III,IV	0.872	0.665	.015	13	view →
COAD	DFS	Median	All	1.000	0.929	.043	12	view →
PDAC	DFS	Median	III,IV	0.670	0.332	.014	7	view →
HNSC	OS	Quartile	All	0.779	0.545	.014	4	view →
LUAD	DFS	Median	III,IV	0.900	0.612	.033	3	view →
GBM	DFS	Median	All	0.479	0.287	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DPH5–CCRCC (DFS)

Open the CCRCC breakdown →