DPH5

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DPH5 mutation is significantly associated with the RNA expression of many other genes, with 507 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPH5-associated genes across cancer lineages are LINC02628, CYP2C19, and RNA5SP414. Each is linked with DPH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPH5-to-partner and partner-to-DPH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02628 grouped by DPH5-low versus DPH5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPH5→partner) and Y-score (partner→DPH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLCALINC02628 →+0.097+5.411<.001.00532
UCECCYP2C19 →+0.034+2.626.004.00232
UCECRNA5SP414 →+0.699+2.769<.001.00232
LUSCRNU6-1290P →+0.501+5.625<.001.00432
LUSCC16orf97 →+0.142+5.625.004.00432
UCECKSR1P1 →+0.133+3.299<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 507 associations by consensus.

LINC02628 by DPH5 expression — BLCA

Box plot of LINC02628 in DPH5-low vs DPH5-high samples in BLCA.

Explore this box plot interactively →

Exploration