DPH5

Across TCGA patient cohorts, DPH5 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPH5-associated genes across cancer lineages are PKC-b-II_pS660, Notch1, and p38-MAPK_pT180_Y182. Each is linked with DPH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPH5-to-partner and partner-to-DPH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by DPH5-low versus DPH5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPH5→partner) and Y-score (partner→DPH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.380	-3.321	.008	.010	3	2
UCEC	Notch1 →	+0.178	+3.321	.016	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.767	-3.169	.001	.019	3	1
UCEC	p62 Lck ligand →	+0.410	+3.009	.016	.019	3	1
UCEC	PDCD4 →	-0.599	-3.321	.015	.010	3	1
UCEC	PKC-delta_pS664 →	-0.176	-2.999	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PKC-b-II_pS660 by DPH5 expression — UCEC

Explore this box plot interactively →