DPH2

Across TCGA patient cohorts, DPH2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPH2-associated genes across cancer lineages are MEK1, p62 Lck ligand, and XBP1. Each is linked with DPH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPH2-to-partner and partner-to-DPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by DPH2-low versus DPH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPH2→partner) and Y-score (partner→DPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.509	+3.169	.003	.019	3	2
UCEC	p62 Lck ligand →	+0.538	+3.321	<.001	.009	3	1
UCEC	XBP1 →	-0.228	-3.308	<.001	.009	3	1
UCEC	ATM →	-0.769	-3.156	<.001	.018	3	1
UCEC	Chk2 →	-0.244	-3.169	.030	.019	3	1
UCEC	Annexin-1 →	+0.853	+2.459	<.001	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by DPH2 expression — UCEC

Explore this box plot interactively →