Across TCGA pan-cancer cohorts, DPF3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DPF3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DPF3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DPF3 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where DPF3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPF3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.420	.006	3	view →
HNSC	Male	All	−2.114	.014	2	view →
LSCC	Male	All	−0.273	.030	2	view →
PDAC	All	All	−0.553	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: DPF3 RNA expression & survival · all DPF3 data types