DPF1

Across TCGA patient cohorts, DPF1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPF1-associated genes across cancer lineages are Caspase-8, Rad50, and 4E-BP1. Each is linked with DPF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPF1-to-partner and partner-to-DPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by DPF1-low versus DPF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPF1→partner) and Y-score (partner→DPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.283	-2.973	.040	.035	3	2
UCEC	Rad50 →	-0.329	-3.169	.013	.020	2	1
UCEC	4E-BP1 →	+0.507	+2.837	<.001	.035	2	1
UCEC	IGFBP2 →	-0.714	-3.169	.045	.020	1	1
UCEC	VHL →	-1.484	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Caspase-8 by DPF1 expression — UCEC

Explore this box plot interactively →