DPF1

Across TCGA cell cohorts, DPF1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DPF1-associated genes across cancer lineages are IDI2, OR7G1, and RNASE8. Each is linked with DPF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPF1-to-partner and partner-to-DPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IDI2 grouped by DPF1-low versus DPF1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPF1→partner) and Y-score (partner→DPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IDI2 →	+0.028	+4.299	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR7G1 →	+0.011	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	RNASE8 →	+0.037	+3.604	<.001	.004	3	1
BLOOD_Leukemia	FAM24A →	+0.064	+4.969	<.001	.003	3	1
SKIN	APELA →	+0.068	+3.292	<.001	.007	1	1
SKIN	NOX1 →	+0.130	+3.443	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

IDI2 by DPF1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →