DPEP3

Across TCGA patient cohorts, DPEP3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPEP3-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1068, and A-Raf_pS299. Each is linked with DPEP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPEP3-to-partner and partner-to-DPEP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by DPEP3-low versus DPEP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPEP3→partner) and Y-score (partner→DPEP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.164	-3.156	.007	.018	3	2
UCEC	EGFR_pY1068 →	-0.256	-2.321	.013	.034	3	1
UCEC	A-Raf_pS299 →	-0.198	-3.700	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.594	+3.584	<.001	.002	3	1
UCEC	p70-S6K_pT389 →	-0.228	-3.169	.003	.018	3	1
UCEC	PCNA →	+0.279	+2.584	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

mTOR_pS2448 by DPEP3 expression — UCEC

Explore this box plot interactively →