DPEP3

Across TCGA cell cohorts, DPEP3 mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DPEP3-associated genes across cancer lineages are ACER1, IGSF22, and OR12D2. Each is linked with DPEP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPEP3-to-partner and partner-to-DPEP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by DPEP3-low versus DPEP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPEP3→partner) and Y-score (partner→DPEP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACER1 →	+0.227	+3.399	.001	.008	3	2
BLOOD_Leukemia	IGSF22 →	+0.420	+3.392	<.001	.007	3	2
LARGE_INTESTINE	OR12D2 →	+0.053	+2.882	<.001	.005	3	1
LARGE_INTESTINE	GUCA1A →	+0.046	+2.841	<.001	.009	3	1
LARGE_INTESTINE	PDE6C →	+0.203	+3.273	.008	.006	2	2
BLOOD_Leukemia	SLC32A1 →	+0.704	+3.486	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

ACER1 by DPEP3 expression — BLOOD_Leukemia

Explore this box plot interactively →