DPEP2

Across TCGA cell cohorts, DPEP2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DPEP2-associated genes across cancer lineages are SLC17A6, OR2B2, and MBD3L1. Each is linked with DPEP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPEP2-to-partner and partner-to-DPEP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC17A6 grouped by DPEP2-low versus DPEP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPEP2→partner) and Y-score (partner→DPEP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC17A6 →	+0.023	+4.977	<.001	.007	3	2
SKIN	OR2B2 →	+0.022	+4.099	<.001	<.001	3	1
SKIN	MBD3L1 →	+0.016	+4.022	<.001	.006	3	1
SKIN	GOLGA6L2 →	+0.073	+3.196	.003	.007	3	1
SKIN	OR5G3 →	+0.105	+3.781	.001	.003	3	1
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SLC17A6 by DPEP2 expression — LARGE_INTESTINE

Explore this box plot interactively →