DPEP1

Across TCGA cell cohorts, DPEP1 mutation is significantly associated with the drug of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DPEP1-associated genes across cancer lineages are Tanespimycin, GSK2110183B, and BAY-MPS1. Each is linked with DPEP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPEP1-to-partner and partner-to-DPEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tanespimycin grouped by DPEP1-low versus DPEP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPEP1→partner) and Y-score (partner→DPEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Tanespimycin →	-0.499	-2.807	.011	.049	2	1
BLOOD_Leukemia	GSK2110183B →	+0.452	+2.655	.009	.044	2	1
BLOOD_Leukemia	BAY-MPS1 →	+0.536	+2.885	.032	.026	1	1
BLOOD_Leukemia	Mitomycin-C →	+0.565	+2.710	.018	.048	1	1
BLOOD_Leukemia	FEN1_3940 →	+0.285	+2.959	.047	.023	1	1
BLOOD_Leukemia	AZD1480 →	+0.325	+2.963	.041	.023	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Tanespimycin by DPEP1 expression — BLOOD_Leukemia

Explore this box plot interactively →