DPCD

Across TCGA pan-cancer cohorts, DPCD mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DPCD data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DPCD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DPCD expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

CCRCC, COAD, and UCEC are the cancer types where DPCD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.743	0.964	.008	7	view →
COAD	DFS	Median	IV	0.565	1.000	.036	6	view →
UCEC	DFS	Quartile	All	0.966	0.826	.035	4	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	4	view →
PDAC	DFS	Median	II,III,IV	0.422	0.280	.034	3	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
GBM	DFS	Median	All	0.692	0.805	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DPCD–CCRCC (DFS)

Open the CCRCC breakdown →