DPCD

Across TCGA pan-cancer cohorts, DPCD mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DPCD’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where DPCD mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DPCD is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

CCRCC, COAD, and LSCC are the cancer types where DPCD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPCD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.726	<.001	11	view →
COAD	All	III,IV	+0.232	<.001	7	view →
LSCC	All	III,IV	+0.346	.016	2	view →
HNSC	All	II,III,IV	−0.147	.012	2	view →
LUAD	Female	III,IV	−0.370	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

DPCD–CCRCC

Open the CCRCC breakdown →