DOT1L

Across TCGA patient cohorts, DOT1L RNA expression is significantly associated with the protein abundance of many other proteins, with 15,491 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DOT1L-associated proteins across cancer lineages are KHSRP, KHSRP_S480, and CHAF1A. Each is linked with DOT1L in more than 4 cancer types. Because this analysis shows association rather than direction, both DOT1L-to-partner and partner-to-DOT1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOT1L versus KHSRP in GBM, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DOT1L→partner) and Y-score (partner→DOT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KHSRP →	+0.310	+0.727	<.001	<.001	3	5
LSCC	KHSRP_S480 →	+0.647	+0.625	<.001	<.001	3	5
GBM	CHAF1A →	+0.551	+0.698	<.001	<.001	3	5
GBM	CHAF1B →	+0.689	+0.785	<.001	<.001	3	5
LSCC	DNMT1 →	+0.509	+0.657	<.001	<.001	3	5
UCEC	PRPF4B_S294 →	+0.820	+0.760	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,491 associations by consensus.

DOT1L vs KHSRP — GBM

Explore this scatter interactively →