DOT1L

Across TCGA patient cohorts, DOT1L mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOT1L-associated genes across cancer lineages are MEK1, Rad50, and STAT3_pY705. Each is linked with DOT1L in more than 3 cancer types. Because this analysis shows association rather than direction, both DOT1L-to-partner and partner-to-DOT1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by DOT1L-low versus DOT1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOT1L→partner) and Y-score (partner→DOT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.399	+2.392	<.001	<.001	3	4
UCEC	Rad50 →	-0.253	-1.986	<.001	.002	3	3
UCEC	STAT3_pY705 →	-0.241	-1.127	.001	.037	3	3
UCEC	Caspase-7-cleavedD198 →	+0.625	+1.671	<.001	.003	3	3
UCEC	4E-BP1 →	+0.301	+1.784	<.001	<.001	3	3
BRCA	NF2 →	+0.275	+2.814	.016	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

MEK1 by DOT1L expression — UCEC

Explore this box plot interactively →