DOT1L

Across TCGA cell cohorts, DOT1L RNA expression is significantly associated with the RNA expression of many other genes, with 11,823 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOT1L-associated genes across cancer lineages are SAFB, CHAF1A, and KHSRP. Each is linked with DOT1L in more than 19 cancer types. Because this analysis shows association rather than direction, both DOT1L-to-partner and partner-to-DOT1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOT1L versus SAFB in SOFT_TISSUE, with a Pearson correlation of 0.89.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOT1L→partner) and Y-score (partner→DOT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SAFB →	+1.058	+1.437	<.001	<.001	3	20
LIVER	CHAF1A →	+1.389	+1.605	<.001	.001	3	20
BLOOD_Lymphoma	KHSRP →	+1.385	+1.116	<.001	<.001	3	19
LARGE_INTESTINE	ILF3 →	+0.973	+1.170	<.001	<.001	3	19
BREAST	DNMT1 →	+1.182	+1.297	<.001	<.001	3	19
BREAST	HCFC1 →	+1.133	+1.278	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,823 associations by consensus.

DOT1L vs SAFB — SOFT_TISSUE

Explore this scatter interactively →