DOT1L

Across TCGA cell cohorts, DOT1L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,827 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DOT1L-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Epigenetic regulation of gene expression, and Positive regulation of T-helper 17 cell lineage commitment. Each is linked with DOT1L in more than 18 cancer types. Because this analysis shows association rather than direction, both DOT1L-to-partner and partner-to-DOT1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by DOT1L-low versus DOT1L-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOT1L→partner) and Y-score (partner→DOT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Subtelomeric heterochromatin formation →	+0.147	+1.395	<.001	<.001	3	19
STOMACH	Epigenetic regulation of gene expression →	+0.079	+1.105	.005	.001	3	19
STOMACH	Positive regulation of T-helper 17 cell lineage commitment →	+0.263	+1.155	.001	.002	3	18
BONE	DNA replication-dependent chromatin assembly →	+0.230	+1.607	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Regulation of protein localization to chromatin →	+0.125	+0.917	.001	.001	3	17
BONE	Cytoplasm protein quality control →	+0.140	+1.155	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,827 associations by consensus.

Subtelomeric heterochromatin formation by DOT1L expression — BONE

Explore this box plot interactively →