DOT1L

Across TCGA cell cohorts, DOT1L mutation is significantly associated with the RNA expression of many other genes, with 1,966 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOT1L-associated genes across cancer lineages are ASCC1, HMGN4, and AKAP3. Each is linked with DOT1L in more than 2 cancer types. Because this analysis shows association rather than direction, both DOT1L-to-partner and partner-to-DOT1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASCC1 grouped by DOT1L-low versus DOT1L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOT1L→partner) and Y-score (partner→DOT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASCC1 →	+0.562	+3.321	.003	.003	3	3
LARGE_INTESTINE	HMGN4 →	+0.540	+2.743	<.001	.001	3	3
BLOOD_Leukemia	AKAP3 →	+0.513	+1.837	<.001	.009	3	3
SOFT_TISSUE	CD1A →	+0.019	+3.584	<.001	.004	3	2
SOFT_TISSUE	TSSK2 →	+0.547	+3.876	<.001	.003	3	2
BLOOD_Lymphoma	CST11 →	+0.724	+3.544	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,966 associations by consensus.

ASCC1 by DOT1L expression — LARGE_INTESTINE

Explore this box plot interactively →