DOP1B

Across TCGA pan-cancer cohorts, DOP1B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DOP1B data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DOP1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DOP1B expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where DOP1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	1.000	0.331	.004	34	view →
CCRCC	DFS	Tertile	III,IV	0.321	0.688	.002	17	view →
PDAC	OS	Median	III,IV	1.000	0.537	.008	10	view →
LUAD	OS	Median	All	0.669	0.951	.021	5	view →
LSCC	OS	Median	III,IV	0.951	0.762	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DOP1B–UCEC (DFS)

Open the UCEC breakdown →