DOP1B

Across TCGA patient cohorts, DOP1B mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOP1B-associated genes across cancer lineages are ATM, 4E-BP1, and GAPDH. Each is linked with DOP1B in more than 4 cancer types. Because this analysis shows association rather than direction, both DOP1B-to-partner and partner-to-DOP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DOP1B-low versus DOP1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOP1B→partner) and Y-score (partner→DOP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.435	-1.861	<.001	.001	3	5
STAD	4E-BP1 →	+0.316	+2.459	.014	.019	3	4
COAD	GAPDH →	+0.627	+2.178	.008	.035	2	4
UCEC	PCNA →	+0.196	+1.536	<.001	.001	3	3
BLCA	CD49b →	+0.289	+1.584	.014	.035	3	3
UCEC	eIF4E →	+0.135	+1.362	.012	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

ATM by DOP1B expression — UCEC

Explore this box plot interactively →