DOP1B

Across TCGA cell cohorts, DOP1B mutation is significantly associated with the RNA expression of many other genes, with 1,467 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOP1B-associated genes across cancer lineages are NISCH, SERGEF, and CPSF4. Each is linked with DOP1B in more than 3 cancer types. Because this analysis shows association rather than direction, both DOP1B-to-partner and partner-to-DOP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NISCH grouped by DOP1B-low versus DOP1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOP1B→partner) and Y-score (partner→DOP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NISCH →	+0.562	+1.889	.002	<.001	3	3
BLOOD_Leukemia	SERGEF →	+0.606	+2.837	.004	<.001	3	3
BLOOD_Leukemia	CPSF4 →	+0.443	+3.367	.003	.002	3	3
BLOOD_Leukemia	PUSL1 →	+0.482	+3.459	.002	.002	3	3
BLOOD_Leukemia	FAM216B →	+0.049	+1.944	.003	.003	3	3
BLOOD_Leukemia	ZC3H6 →	+0.914	+2.837	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,467 associations by consensus.

NISCH by DOP1B expression — LARGE_INTESTINE

Explore this box plot interactively →