DONSON

Across TCGA patient cohorts, DONSON protein abundance is significantly associated with the RNA expression of many other genes, with 1,194 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DONSON-associated genes across cancer lineages are RRAD, MIR765, and PHF21A. Each is linked with DONSON in more than 1 cancer types. Because this analysis shows association rather than direction, both DONSON-to-partner and partner-to-DONSON results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DONSON versus RRAD in LSCC, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DONSON→partner) and Y-score (partner→DONSON) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RRAD →	+2.599	+0.750	.007	.008	3	2
BRCA	MIR765 →	-1.314	-0.900	.002	<.001	3	2
LSCC	PHF21A →	-0.438	-0.640	.002	.002	3	2
BRCA	RBFOX2 →	+0.893	+0.575	.001	.006	3	1
BRCA	BRD1 →	+0.781	+0.699	.004	.001	3	1
BRCA	RASSF2 →	+1.088	+0.709	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,194 associations by consensus.

DONSON vs RRAD — LSCC

Explore this scatter interactively →