DONSON

Across TCGA patient cohorts, DONSON mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DONSON-associated genes across cancer lineages are ATM, eEF2, and mTOR_pS2448. Each is linked with DONSON in more than 2 cancer types. Because this analysis shows association rather than direction, both DONSON-to-partner and partner-to-DONSON results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DONSON-low versus DONSON-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DONSON→partner) and Y-score (partner→DONSON) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.449	-3.156	.028	.018	3	3
UCEC	eEF2 →	+0.462	+3.169	.004	.018	3	2
UCEC	mTOR_pS2448 →	-0.152	-2.000	.023	.032	3	2
UCEC	Caspase-7-cleavedD198 →	+0.813	+3.189	.002	.010	3	2
UCEC	EGFR_pY1068 →	-0.304	-2.700	.007	.006	3	1
UCEC	A-Raf_pS299 →	-0.148	-3.169	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ATM by DONSON expression — UCEC

Explore this box plot interactively →