DONSON

Across TCGA cell cohorts, DONSON RNA expression is significantly associated with the go_rna of many other GO terms, with 3,730 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DONSON-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Regulation of chromosome separation, and Negative regulation of metaphase/anaphase transition of cell cycle. Each is linked with DONSON in more than 17 cancer types. Because this analysis shows association rather than direction, both DONSON-to-partner and partner-to-DONSON results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by DONSON-low versus DONSON-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DONSON→partner) and Y-score (partner→DONSON) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of mitotic sister chromatid separation →	+0.126	+0.810	.002	.004	3	18
OESOPHAGUS	Regulation of chromosome separation →	+0.163	+0.838	.005	.009	3	18
KIDNEY	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.129	+0.782	.001	.004	3	17
KIDNEY	Negative regulation of chromosome separation →	+0.129	+0.782	.001	.004	3	17
KIDNEY	Negative regulation of mitotic sister chromatid separation →	+0.138	+0.766	.001	.005	3	17
KIDNEY	Negative regulation of sister chromatid segregation →	+0.138	+0.766	.001	.005	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,730 associations by consensus.

Regulation of mitotic sister chromatid separation by DONSON expression — KIDNEY

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