DONSON

Across TCGA cell cohorts, DONSON mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DONSON-associated genes across cancer lineages are GJD2, OR10W1, and ACSM6. Each is linked with DONSON in more than 1 cancer types. Because this analysis shows association rather than direction, both DONSON-to-partner and partner-to-DONSON results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by DONSON-low versus DONSON-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DONSON→partner) and Y-score (partner→DONSON) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD2 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.022	+4.169	.001	.007	3	1
LARGE_INTESTINE	OR10Q1 →	+0.129	+3.920	<.001	.005	3	1
LARGE_INTESTINE	PNLIPRP1 →	+0.049	+3.920	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GJD2 by DONSON expression — LARGE_INTESTINE

Explore this box plot interactively →